52. Erythropoietic inhibitors in plasma and urine

Plasma Erythropoietic Factor in Anemic Human Patients

By T. C. PRENTICE AND E. A. MIIIAND T HE EXISTENCE of a humoral erythropoietic stimulating factor which controls red cell productiomi has been suspected for mnamiy years. Carmiot amid I)eulamidre’ postulated in 1906 that such might be true. Imi 1950 Reissmanm, usimig paral)iotic rats, published convincing experimnental evidemice of a circubatimig erythropoietic factor imiduced by placimig one m...

hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...

Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria.

Congenital erythropoietic porphyria (CEP) is a rare autosomal recessive disorder characterized by uroporphyrinogen III synthase (UROS) deficiency resulting in massive porphyrin accumulation in blood cells, which is responsible for hemolytic anemia and skin photosensitivity. Among the missense mutations actually described up to now in CEP patients, the C73R and the P248Q mutations lead to a prof...

Studies of plasma erythropoietic factor in anemic human patients.

Evaluation of plasma erythropoietic-stimulating factors in anemic uremic patients.

HE ASSOCIATION of a moderately severe normochromic, normocytic anemia with chronic renal disease is well recognized. Diminished erythropoiesis,’3 hemolysis1’3’4 and hemorrhage5’#{176} have all been shown to contribute to the development of anemia in azotemic patients. However, diminished red cell production appears to be the predominant mechanism in renal anemia. The dynamics of this failure of...